Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus
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Production of Clavulanic Acid by Streptomyces clavuligerus in Batch Cultures with Using Wheat Bran as the Source of Carbon
Nowadays Microbial biotechnology is considered as one of the most important and profitable branches of industry. In this approach, by using the generator microorganisms, We are able to produce biotechnological products, with higher efficiency. Clavulanic acid is being used in combination with commonly used beta-lactam antibiotics in order to fight against bacterial infections that are resistant...
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The levels of several enzymes involved in assimilation of different nitrogen compounds were investigated in Streptomyces clavuligerus in relation to the nitrogen source supplied to the cultures. Threonine dehydratase, serine dehydratase, proline dehydrogenase, histidase and urocanase were not decreased in the presence of ammonium. The latter two enzymes were induced by histidine in the culture ...
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This work describes isolation and characterization of Streptomyces clavuligerus mutants resistant to the lysine analogue S-(2-aminoethyl)-L-cysteine (AEC). The mutation to AEC resistance was shown to affect the feedback regulation of aspartokinase; 70% of the mutants isolated had aspartokinase activity insensitive to concerted feedback inhibition by lysine plus threonine. Among these mutants, 7...
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Carboxyethylarginine synthase is the first dedicated enzyme of clavam biosynthesis in Streptomyces clavuligerus and is present in two isoforms encoded by two separate genes. When grown on a liquid soy medium, strains with ceaS1 deleted showed only a mild reduction of clavam biosynthesis, while disruption of ceaS2 abolished all clavam biosynthesis. Creation of an in-frame ceaS2 deletion mutant t...
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β-lactam antibiotics are among the most popular classes of antibacterial agents, whose mechanism of action consists on the inhibition of bacterial cell wall synthesis.1 The production of β-lactamase is the most important mechanism for bacterial resistance to β-lactam antibiotics.2 Secondary metabolites produced by bacteria exhibit potent biological activities and have been developed extensively...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1978
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.14.2.159